Figure 7. Schematic representation of the interactions between the hypothalamic-pituitary-adrenal (HPA) axis and the thyroid and immune function. CRH: corticotropin-releasing hormone; STS: somatostatin; TRH: thyrotropin releasing hormone; TSH: thyroid stimulating hormone; T4: thyroxine; T3: triiodothyronine; TNF-α: tumor necrosis factor-α; IL-1: interleukin-1; IL-6: interleukin-6. Activation is represented by solid green lines and inhibition by dashed red lines.