Figure 3b-3: Densely granulated somatotroph adenoma. Densely granulated adenomas consist of monomorphic cells that are eosinophilic on HE stain (top left) and intensely orangeophilic on PAS-OG histochemistry (top right). They show strong, diffuse GH expression (bottom left) and an evenly distributed, cell-membrane-anchored keratin cytoskeleton (bottom right).