Figure 15.Correlations of systemic glucose appearance with peak plasma glucose concentration and molar ratio of plasma insulin to glucagon in the study subjects. Solid symbols represent subjects with impaired glucose tolerance, and open symbols normal subjects. Squares represent obese subjects, and circles nonobese subjects. (Copyright 1992 by the Massachusetts Medical Society. Republished with permission of Massachusetts Medical Society from Mitrakou et al. Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med 326:22-29, 1992.)