Figure 7: Intracellular circulation of the GR.

Circulation of GRa between the cytoplasm and the nucleus, and its transactivation or transrepressive activities (from (363)). GRa is also known to translocate into mitochondria and lysosomes. These actions are associated with specific cellular functions.

GR: glucocorticoid receptor; GRE: glucocorticoid responsive element; TFREs: transcription factor responsive elements; HSPs: heat shock proteins; TF: transcription factor