Figure 2: Genomic and complementary DNA, and protein structures of the human (h) GR, functional distribution of the GR, and the isoforms produced through alternative splicing.
The hGR gene consists of 10 exons. Exon 1 is untranslated region, exon 2 codes for the immunogenic domain (A/B), exon 3 and 4 for the DNA-binding domain (C), and exons 5-9 for the hinge region (D) and the ligand-binding domain (E). GR does not contain an F region in contrast to the other steroid hormone receptors. The GR gene contains two terminal exons 9 (exon 9 and 9) alternatively spliced to produce the classic GR and the nonligand-binding GR. C-terminal gray colored domains in GR and GR show their specific portions. Locations of several functional domains are also indicated.
AF-1 and -2: activation function 1 and 2; DBD; DNA-binding domain; HD: hinge region; LBD: Ligand-binding domain; NTD: N-terminal region, NL1 and 2: Nuclear translocation signal 1 and 2.