![](https://www.endotext.org/wp-content/uploads/2014/08/gut2-fig37.png)
Figure 37. PI3K/Akt pathway integrates signals from growth factor receptors, stress and available nutrients. mTOR, an intracellular serine-threonine kinase is centrally located downstream of PI3K.mTOR is a master regulator involved in translation of proteins critical for cell growth, proliferation and angiogenesis in response to upstream signals.