Figure 2.The linearized structures of the mineralocorticoid receptor gene, mRNAs and protein. The MR gene consists of 10 exons. The MR has two exons 1 (exon 1αand exon 1β), each with an alternative promoter; however, the finally translated MR protein is the same. Exons 1 are untranslated regions, exon 2 codes for the immunogenic domain (A/B), exons 3 and 4 for the DNA-binding domain (C), and exons 5-9 for the hinge region (D) and the ligand-binding domain (E). (From .Arai K, Shibasaki T, Chrousos GP. Pseudohypoaldosteronism: sporadic and familial mineralocorticoid resistance. In: Chrousos GP. Olefsky JM, Samols E, eds. Hormone Resistance and Hypersensitivity States. New York: Lippincott Williams & Wilkins; in press with permission)