Figure 11. Adverse events associated with testosterone therapy in randomized trials. The odds ratios for erythrocytosis and cardiovascular events in randomized testosterone trials derived from meta-analyses published by Calof et al 2005 and Haddad et al 2007, respectively are shown in the upper panel. The figure was reproduced with permission from Spitzer et al, Nature Reviews in Endocrinology 2013.

The lower panel shows the relative risk of prostate events and the associated 95% confidence intervals in a meta-analysis of randomized testosterone trials. Data were derived from a meta-analysis by Fernandez-Balsells 2010, and the figure reproduced with permission from Spitzer et al, Nature Reviews in Endocrinology 2013.