Figure 2.Insulin signals the intake of nutrients and acts as measure of energy stores in the adipose tissue. Both basal and nutrient-induced insulin release increase as body fat increases to maintain normal glucose homeostasis in the presence of insulin resistance, which develops in concert with the greater fat depots in the obese subject. It has been hypothesized that this increase in insulin secretion thus results in greater insulin delivery to the brain, where it attempts to limit further weight gain.