![](https://www.endotext.org/wp-content/uploads/guthormone/2/figure58.jpg)
Figure 58. PI3K/Akt pathway integrates signals from growth factor receptors, stress and available nutrients. mTOR, an intracellular serine-threonine kinase is centrally located downstream of PI3K.mTOR is a master regulator involved in translation of proteins critical for cell growth, proliferation and angiogenesis in response to upstream signals.