Figure 9. Models of the mechanism of ligand activation of the insulin receptor tyrosine kinase. A: The "yo-yo" model. From ref. 14. B: The TM domain ligand-induced separation model. From ref. 74. C: The TM domain ligand-induced approximation model. From ref. 75. D. The "rotation model". From reference 24, used with permission. Figure adapted from reference 40, used with permission.
See text for explanation.