etx-dm-ch3-fig9

Figure 9. Models of the mechanism of ligand activation of the insulin receptor tyrosine kinase. A: The "yo-yo" model. From ref. 14. B: The TM domain ligand-induced separation model. From ref. 74. C: The TM domain ligand-induced approximation model. From ref. 75. D. The "rotation model". From reference 24, used with permission. Figure adapted from reference 40, used with permission. See text for explanation.

Figure 9. Models of the mechanism of ligand activation of the insulin receptor tyrosine kinase. A: The “yo-yo” model. From ref. 14. B: The TM domain ligand-induced separation model. From ref. 74. C: The TM domain ligand-induced approximation model. From ref. 75. D. The “rotation model”. From reference 24, used with permission. Figure adapted from reference 40, used with permission.
See text for explanation.

Figure 9. Models of the mechanism of ligand activation of the insulin receptor tyrosine kinase. A: The "yo-yo" model. From ref. 14. B: The TM domain ligand-induced separation model. From ref. 74. C: The TM domain ligand-induced approximation model. From ref. 75. D. The "rotation model". From reference 24, used with permission. Figure adapted from reference 40, used with permission.
See text for explanation.