Figure 13: Interaction model of Gas5 RNA “GRE” with GR DBD and the effect of Gas5 on GRa-induced transcriptional activity.

A: 3-Dimenstional structure of Gas5 “GRE”-mimic and its interaction model with the GR DBD. From (252).

B: Schematic model of the effect of Gas5 on GR-induced transcriptional activity.

Gas5 accumulated in response to growth arrest/starvation binds GR DBD and attenuates GR-induced transcriptional activity by competing with DNA GREs located in the promoter region of glucocorticoid-responsive genes.