Figure 5. Plasma ACTH and serum cortisol response to stimulation with human CRH (100 µg IV) in normal control subjects (mean +/- SEM; shaded area), in 6 patients with subclinical Cushing´s syndrome, and in 6 patients with overt adrenal Cushing´s syndrome. Circles = subclinical Cushing´s syndrome; diamonds = adrenal Cushing´s syndrome; shaded areas = normal subjects. (From Allolio, B., Adrenal Incidentalomas. Adrenal Disorders, ed. C.G. Margioris AN. 2001, Totowa: Humana Press Inc. 249 – 261; with permission.)