Figure 1. This Figure illustrates the pancreato-biliary complex including the ductular system. The acina/ductal
system contains proto-differentiated stem cells capable of differentiating into a variety of endocrine cells (4).
In addition the pancreatic duct glands can grow and proliferate developing pancreatic Intraductal neoplasms
(PANINS) forming the basis of PNETs and NFPNETS with different levels of differentiation and
dedifferentiation.