ENDOTXTFIG02B

Figure 2b. Specific actions of 5α-Dihydrotestosterone (DHT). T is synthesized in the testis under control of luteinizing hormone (LH) from the pituitary. After entering the target cells (in the urogenital sinus, urogenital tubercle, and several additional androgen target tissues) T is metablized to 5α-Dihydrotestosterone (DHT) by the enzyme 5α-Reductase type 2. DHT binds directly to the androgen receptor (AR) and the complex DHT-AR interacts to specific DNA sequences and regulates gene transcription, which can result in differentiation and development of the prostate, the external genitalia and at puberty in several secondary male characteristics.

Figure 2b. Specific actions of 5α-Dihydrotestosterone (DHT). T is synthesized in the testis under control of luteinizing hormone (LH) from the pituitary. After entering the target cells (in the urogenital sinus, urogenital tubercle, and several additional androgen target tissues) T is metablized to 5α-Dihydrotestosterone (DHT) by the enzyme 5α-Reductase type 2. DHT binds directly to the androgen receptor (AR) and the complex DHT-AR interacts to specific DNA sequences and regulates gene transcription, which can result in differentiation and development of the prostate, the external genitalia and at puberty in several secondary male characteristics.