Figure 9: GRa binds nGREs as a monomer.

GRa binds nGREs as a monomer at each of its half site (A) in contrast to its binding as a homo-dimer to classic GREs (B). nGREs of the mouse TSLP gene is used as an example.

Images are from RCSB Protein Data Bank (PDB) Website (www.rcsb.org). Image data for GRa interaction with nGREs and classic GREs are DOI: 10.2210/pdb4hn5/pdb and DOI: 10.2210/pdb3g9m/pdb, respectively.