Figure 1. FRAX online for US Caucasian patients. This example shows a 65-year-old woman who has no clinical risk factors for fracture and a femoral neck BMD of 0.582 g/cm2 with a Hologic instrument. The 10-year probability of major osteoporotic fracture is 11% and the 10-year probability of hip fracture is 2.2%. These levels do not meet the Bone Health & Osteoporosis Foundation guidelines for initiation of pharmacological therapy in the US (7). Image reproduced with permission from Eugene McCloskey, University of Sheffield, Sheffield, UK.