Figure 13. Organization of the topologically associated domain (TADs) and chromatin looping promoted by CTCF for differential expression of glucocorticoid-responsive genes. CTCF organizes 3-dimensional chromatin interaction for the formation of TADs and chromatin looping, in cooperating with the cohesion protein complex and other component proteins. Chromatin loop-forming activity of CTCF is essential for differential use of enhancers/promoters by GR-responding genes, and underlies organ/tissue-specific actions of glucocorticoids. Modified from (147).