1. Nieves,DJ, Cnop,M, Retzlaff,B, Walden,CE, Brunzell,JD, Knopp,RH, Kahn,SE: The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat. Diabetes 52:172-179, 2003
2. Poirier,P, Eckel,RH: Obesity and cardiovascular disease. Curr.Atheroscler.Rep. 4:448-453, 2002
3. Denke,MA, Sempos,CT, Grundy,SM: Excess body weight. An under-recognized contributor to dyslipidemia in white American women. Arch.Intern.Med. 154:401-410, 1994
4. Sundquist,J, Winkleby,MA, Pudaric,S: Cardiovascular disease risk factors among older black, Mexican-American, and white women and men: an analysis of NHANES III, 1988-1994. Third National Health and Nutrition Examination Survey. J.Am.Geriatr.Soc. 49:109-116, 2001
5. Hickman,TB, Briefel,RR, Carroll,MD, Rifkind,BM, Cleeman,JI, Maurer,KR, Johnson,CL: Distributions and trends of serum lipid levels among United States children and adolescents ages 4-19 years: data from the Third National Health and Nutrition Examination Survey. Prev.Med. 27:879-890, 1998
6. Rexrode,KM, Carey,VJ, Hennekens,CH, Walters,EE, Colditz,GA, Stampfer,MJ, Willett,WC, Manson,JE: Abdominal adiposity and coronary heart disease in women. JAMA 280:1843-1848, 1998
7. Mittelman,SD, Van Citters,GW, Kirkman,EL, Bergman,RN: Extreme insulin resistance of the central adipose depot in vivo. Diabetes 51:755-761, 2002
8. Bergman,RN, Van Citters,GW, Mittelman,SD, Dea,MK, Hamilton-Wessler,M, Kim,SP, Ellmerer,M: Central role of the adipocyte in the metabolic syndrome. J.Investig.Med. 49:119-126, 2001
9. Bjorntorp,P: Metabolic implications of body fat distribution. Diabetes Care 14:1132-1143, 1991
10. Bjorntorp,P: Metabolic abnormalities in visceral obesity. Ann.Med. 24:3-5, 1992
11. Zwiauer,KF, Pakosta,R, Mueller,T, Widhalm,K: Cardiovascular risk factors in obese children in relation to weight and body fat distribution. J.Am.Coll.Nutr. 11 Suppl:41S-50S, 1992
12. Tershakovec,AM, Kuppler,K: Ethnicity, Insurance Type, and Follow-up in a Pediatric Weight Management Program. Obes.Res. 11:17-20, 2003
13. Zieske,AW, Malcom,GT, Strong,JP: Natural history and risk factors of atherosclerosis in children and youth: the PDAY study. Pediatr.Pathol.Mol.Med. 21:213-237, 2002
14. McGill,HC, Jr., McMahan,CA, Herderick,EE, Zieske,AW, Malcom,GT, Tracy,RE, Strong,JP: Obesity accelerates the progression of coronary atherosclerosis in young men. Circulation 105:2712-2718, 2002
15. Lim,SC, Tan,BY, Chew,SK, Tan,CE: The relationship between insulin resistance and cardiovascular risk factors in overweight/obese non-diabetic Asian adults: the 1992 Singapore National Health Survey. Int.J.Obes.Relat Metab Disord. 26:1511-1516, 2002
16. Hu,D, Hannah,J, Gray,RS, Jablonski,KA, Henderson,JA, Robbins,DC, Lee,ET, Welty,TK, Howard,BV: Effects of obesity and body fat distribution on lipids and lipoproteins in nondiabetic American Indians: The Strong Heart Study. Obes.Res. 8:411-421, 2000
17. Sims,EA, Danforth E Jr, Horton,ES, Bray,GA, Glennon,JA, Salans,LB: Endocrine and metabolic effects of experimental obesity in man. Recent Prog.Horm.Res. 29:457-496, 1973
18. Sharman,MJ, Kraemer,WJ, Love,DM, Avery,NG, Gomez,AL, Scheett,TP, Volek,JS: A ketogenic diet favorably affects serum biomarkers for cardiovascular disease in normal-weight men. J.Nutr. 132:1879-1885, 2002
19. Gower,BA, Weinsier,RL, Jordan,JM, Hunter,GR, Desmond,R: Effects of weight loss on changes in insulin sensitivity and lipid concentrations in premenopausal African American and white women. Am.J.Clin.Nutr. 76:923-927, 2002
20. Muls,E, Kolanowski,J, Scheen,A, Van Gaal,L: The effects of orlistat on weight and on serum lipids in obese patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled, multicentre study. Int.J.Obes.Relat Metab Disord. 25:1713-1721, 2001
21. Dujovne,CA, Zavoral,JH, Rowe,E, Mendel,CM: Effects of sibutramine on body weight and serum lipids: a double-blind, randomized, placebo-controlled study in 322 overweight and obese patients with dyslipidemia. Am.Heart J. 142:489-497, 2001
22. Ditschuneit,HH, Frier,HI, Flechtner-Mors,M: Lipoprotein responses to weight loss and weight maintenance in high-risk obese subjects. Eur.J.Clin.Nutr. 56:264-270, 2002
23. Krebs,JD, Evans,S, Cooney,L, Mishra,GD, Fruhbeck,G, Finer,N, Jebb,SA: Changes in risk factors for cardiovascular disease with body fat loss in obese women. Diabetes Obes.Metab 4:379-387, 2002
24. Dattilo,AM, Kris-Etherton,PM: Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis. Am.J.Clin.Nutr. 56:320-328, 1992
25. Nicklas,BJ, Dennis,KE, Berman,DM, Sorkin,J, Ryan,AS, Goldberg,AP: Lifestyle intervention of hypocaloric dieting and walking reduces abdominal obesity and improves coronary heart disease risk factors in obese, postmenopausal, African-American and Caucasian women. J.Gerontol.A Biol.Sci.Med.Sci. 58:181-189, 2003
26. Castelli,WP: Epidemiology of triglycerides: a view from Framingham. American Journal of Cardiology. 70:3H-9H, 1992
27. Balkau,B, Eschwege,E: Insulin resistance: an independent risk factor for cardiovascular disease? Diabetes, Obesity & Metabolism. 1:S23-S31, 1999
28. Lamarche,B, Tchernof,A, Mauriege,P, Cantin,B, Dagenais,GR, Lupien,PJ, Despres,JP: Fasting insulin and apolipoprotein B levels and low-density lipoprotein particle size as risk factors for ischemic heart disease. JAMA. 279:1955-1961, 1998
29. Manolio,TA, Savage,PJ, Burke,GL, Liu,KA, Wagenknecht,LE, Sidney,S, Jacobs,DR, Jr., Roseman,JM, Donahue,RP, Oberman,A: Association of fasting insulin with blood pressure and lipids in young adults. The CARDIA study. Arteriosclerosis. 10:430-436, 1990
30. Haffner,SM, Mykkanen,L, Stern,MP, Valdez,RA, Heisserman,JA, Bowsher,RR: Relationship of proinsulin and insulin to cardiovascular risk factors in nondiabetic subjects. Diabetes. 42:1297-1302, 1993
31. Bhopal,R, Unwin,N, White,M, Yallop,J, Walker,L, Alberti,KG, Harland,J, Patel,S, Ahmad,N, Turner,C, Watson,B, Kaur,D, Kulkarni,A, Laker,M, Tavridou,A: Heterogeneity of coronary heart disease risk factors in Indian, Pakistani, Bangladeshi, and European origin populations: cross sectional study. BMJ. 319:215-220, 1999
32. Laws,A, Jeppesen,JL, Maheux,PC, Schaaf,P, Chen,YD, Reaven,GM: Resistance to insulin-stimulated glucose uptake and dyslipidemia in Asian Indians. Arterioscler.Thromb. 14:917-922, 1994
33. Howard,BV, Knowler,WC, Vasquez,B, Kennedy,AL, Pettitt,DJ, Bennett,PH: Plasma and lipoprotein cholesterol and triglyceride in the Pima Indian population. Comparison of diabetics and nondiabetics. Arteriosclerosis. 4:462-471, 1984
34. Gray,RS, Fabsitz,RR, Cowan,LD, Lee,ET, Howard,BV, Savage,PJ: Risk factor clustering in the insulin resistance syndrome. The Strong Heart Study. American Journal of Epidemiology. 148:869-878, 1998
35. Sparks,JD, Sparks,CE: Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion. Biochimica et Biophysica Acta. 1215:9-32, 1994
36. Kendrick,JS, Wilkinson,J, Cartwright,IJ, Lawrence,S, Higgins,JA: Regulation of the assembly and secretion of very low density lipoproteins by the liver. Biological Chemistry. 379:1033-1040, 1998
37. Taghibiglou,C, Carpentier,A, Van Iderstine,SC, Chen,B, Rudy,D, Aiton,A, Lewis,GF, Adeli,K: Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. Evidence for enhanced lipoprotein assembly, reduced intracellular ApoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamster model. [erratum appears in J Biol Chem 2001 Jun 8;276(23):20804.]. Journal of Biological Chemistry. 275:8416-8425, 2000
38. Lin,MC, Gordon,D, Wetterau,JR: Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression. Journal of Lipid Research. 36:1073-1081, 1995
39. Sato,R, Miyamoto,W, Inoue,J, Terada,T, Imanaka,T, Maeda,M: Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription. Journal of Biological Chemistry. 274:24714-24720, 1999
40. Pan,M, Liang Js,JS, Fisher,EA, Ginsberg,HN: The late addition of core lipids to nascent apolipoprotein B100, resulting in the assembly and secretion of triglyceride-rich lipoproteins, is independent of both microsomal triglyceride transfer protein activity and new triglyceride synthesis. Journal of Biological Chemistry. 277:4413-4421, 2002
41. Miyashita,Y, Shirai,K, Itoh,Y, Sasaki,H, Totsuka,M, Murano,T, Watanabe,H: Low lipoprotein lipase mass in preheparin serum of type 2 diabetes mellitus patients and its recovery with insulin therapy. Diabetes Research & Clinical Practice.56(3):181-7, 2002
42. Taskinen,MR: Lipoprotein lipase in diabetes. [Review] [92 refs]. Diabetes-Metabolism Reviews. 3:551-570, 1987
43. Streicher,R, Kotzka,J, Muller-Wieland,D, Siemeister,G, Munck,M, Avci,H, Krone,W: SREBP-1 mediates activation of the low density lipoprotein receptor promoter by insulin and insulin-like growth factor-I. Journal of Biological Chemistry. 271:7128-7133, 1996
44. Malmstrom,R, Packard,CJ, Watson,TD, Rannikko,S, Caslake,M, Bedford,D, Stewart,P, Yki-Jarvinen,H, Shepherd,J, Taskinen,MR: Metabolic basis of hypotriglyceridemic effects of insulin in normal men. Arteriosclerosis Thrombosis & Vascular Biology. 17:1454-1464, 1997
45. Malmstrom,R, Packard,CJ, Caslake,M, Bedford,D, Stewart,P, Yki-Jarvinen,H, Shepherd,J, Taskinen,MR: Effects of insulin and acipimox on VLDL1 and VLDL2 apolipoprotein B production in normal subjects. [erratum appears in Diabetes 1998 Sep;47(9):1532.]. Diabetes. 47:779-787, 1998
46. Malmstrom,R, Packard,CJ, Caslake,M, Bedford,D, Stewart,P, Yki-Jarvinen,H, Shepherd,J, Taskinen,MR: Defective regulation of triglyceride metabolism by insulin in the liver in NIDDM. Diabetologia. 40:454-462, 1997
47. Ruotolo,G, Micossi,P, Galimberti,G, Librenti,MC, Petrella,G, Marcovina,S, Pozza,G, Howard,BV: Effects of intraperitoneal versus subcutaneous insulin administration on lipoprotein metabolism in type I diabetes. Metabolism: Clinical & Experimental. 39:598-604, 1990
48. Yu,KC, Cooper,AD: Postprandial lipoproteins and atherosclerosis. [Review] [287 refs]. Frontiers in Bioscience. 6:D332-D354, 2001
49. Jeppesen,J, Hollenbeck,CB, Zhou,MY, Coulston,AM, Jones,C, Chen,YD, Reaven,GM: Relation between insulin resistance, hyperinsulinemia, postheparin plasma lipoprotein lipase activity, and postprandial lipemia. Arteriosclerosis Thrombosis & Vascular Biology. 15:320-324, 1995
50. Boquist,S, Hamsten,A, Karpe,F, Ruotolo,G: Insulin and non-esterified fatty acid relations to alimentary lipaemia and plasma concentrations of postprandial triglyceride-rich lipoproteins in healthy middle-aged men. Diabetologia. 43:185-193, 2000
51. Schneeman,BO, Kotite,L, Todd,KM, Havel,RJ: Relationships between the responses of triglyceride-rich lipoproteins in blood plasma containing apolipoproteins B-48 and B-100 to a fat-containing meal in normolipidemic humans. Proceedings of the National Academy of Sciences of the United States of America. 90:2069-2073, 1993
52. Boquist,S, Ruotolo,G, Tang,R, Bjorkegren,J, Bond,MG, de Faire,U, Karpe,F, Hamsten,A: Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men. Circulation. 100:723-728, 1999
53. Descamps,O, Bilheimer,D, Herz,J: Insulin stimulates receptor-mediated uptake of apoE-enriched lipoproteins and activated alpha 2-macroglobulin in adipocytes. Journal of Biological Chemistry. 268:974-981, 1993
54. Ko,KW, Avramoglu,RK, McLeod,RS, Vukmirica,J, Yao,Z: The insulin-stimulated cell surface presentation of low density lipoprotein receptor-related protein in 3T3-L1 adipocytes is sensitive to phosphatidylinositide 3-kinase inhibition. Biochemistry. 40:752-759, 2001
55. Phillips,C, Owens,D, Collins,P, Tomkin,GH: Microsomal triglyceride transfer protein: does insulin resistance play a role in the regulation of chylomicron assembly? Atherosclerosis. 160:355-360, 2002
56. Phillips,C, Bennett,A, Anderton,K, Owens,D, Collins,P, White,D, Tomkin,GH: Intestinal rather than hepatic microsomal triglyceride transfer protein as a cause of postprandial dyslipidemia in diabetes. Metabolism: Clinical & Experimental.51(7):847-52, 2002
57. Kwiterovich,PO, Jr.: Clinical relevance of the biochemical, metabolic, and genetic factors that influence low-density lipoprotein heterogeneity. Am.J.Cardiol. 90:30i-47i, 2002
58. Lund-Katz,S, Laplaud,PM, Phillips,MC, Chapman,MJ: Apolipoprotein B-100 conformation and particle surface charge in human LDL subspecies: implication for LDL receptor interaction. Biochemistry. 37:12867-12874, 1998
59. Haffner,SM, Mykkanen,L, Valdez,RA, Paidi,M, Stern,MP, Howard,BV: LDL size and subclass pattern in a biethnic population. Arteriosclerosis & Thrombosis. 13:1623-1630, 1993
60. Howard,BV, Robbins,DC, Sievers,ML, Lee,ET, Rhoades,D, Devereux,RB, Cowan,LD, Gray,RS, Welty,TK, Go,OT, Howard,WJ: LDL cholesterol as a strong predictor of coronary heart disease in diabetic individuals with insulin resistance and low LDL: The Strong Heart Study. Arteriosclerosis Thrombosis & Vascular Biology. 20:830-835, 2000
61. Reaven,GM, Chen,YD, Jeppesen,J, Maheux,P, Krauss,RM: Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles. J.Clin.Invest 92:141-146, 1993
62. Frenais,R, Nazih,H, Ouguerram,K, Maugeais,C, Zair,Y, Bard,JM, Charbonnel,B, Magot,T, Krempf,M: In vivo evidence for the role of lipoprotein lipase activity in the regulation of apolipoprotein AI metabolism: a kinetic study in control subjects and patients with type II diabetes mellitus. J.Clin.Endocrinol.Metab 86:1962-1967, 2001
63. van't Hooft,FM, Ruotolo,G, Boquist,S, de Faire,U, Eggertsen,G, Hamsten,A: Human evidence that the apolipoprotein A-II gene is implicated in visceral fat accumulation and metabolism of triglyceride-rich lipoproteins. Circulation. 104:1223-1228, 2001
64. Tschritter,O, Fritsche,A, Thamer,C, Haap,M, Shirkavand,F, Rahe,S, Staiger,H, Maerker,E, Haring,H, Stumvoll,M: Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes 52:239-243, 2003