Table of Contents

Introduction

Growth hormone- structure and physiology

Central regulation of GH secretion

Peripheral regulation of GH secretion

IGF-I - Structure and Function

IGF Binding Proteins (IGFBPs)

Clinical features of Acromegaly

Symptoms and Signs

Morbidity and mortality in acromegaly

INVESTIGATIONS in the patient with acromegaly

Confirmation of diagnosis and biochemical assessment

Radiological Assessment

Neuro-opthalmological Testing

Assessment of pituitary function

MANAGEMENT of Acromegaly

Surgery for Acromegaly

Pituitary Irradiation in Acromegaly

Medical therapy

Practical approach to management of the patient with acromegaly

References