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INTRODUCTION

CAUSES OF GH DEFICIENCY IN ADULTS

THE DIAGNOSIS OF GH DEFICIENCY

CLINICAL FEATURES OF GH DEFICIENCY IN ADULTS

RESPONSE TO GH REPLACEMENT IN ADULT GROWTH HORMONE DEFICIENCY

QUALITY OF LIFE AND PSYCHOLOGICAL WELL-BEING

BODY COMPOSITION: FAT MASS, FAT DISTRIBUTION AND LEAN BODY MASS

EXERCISE CAPACITY AND PERFORMANCE

CARBOHYDRATE METABOLISM AND INSULIN SENSITIVITY

SERUM LIPOPROTEIN PROFILES

CARDIAC AND PERIPHERAL VASCULAR EFFECTS

INDICES OF BONE REMODELLING AND BONE MINERAL DENSITY

SELECTING PATIENTS FOR GROWTH HORMONE REPLACEMENT

ESTABLISHING THE MAINTENANCE GH DOSE

ADVERSE EFFECTS

GH REPLACEMENT IN ELDERLY HYPOPITUITARY PATIENTS

TRANSITION BETWEEN PAEDIATRIC AND ADULT CARE FOR CHILDHOOD ONSET GHD

COSTS VERSUS BENEFITS OF GH REPLACEMENT THERAPY

TREATMENT COSTS

ECONOMIC BENEFITS OF GH REPLACEMENT