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	PART 1. ANATOMY, CELL BIOLOGY AND PHYSIOLOGY OF THE HYPOTHALAMO-POSTERIOR PITUITARY AXIS
	1. The anatomy of the Neurohypophysis
	2. Molecular-cell biology of Vasopressin and Oxytocin
	2.1. The Vasopressin-Neurophysin and Oxytocin-Neurophysin genes
	2.2. Synthesis, release, and metabolism of Vasopressin and Oxytocin
	3. The physiology of Vasopressin
	3.1. Vasopressin receptors
	3.2. Vasopressin and renal water handling
	3.3. Regulation of Vasopressin release
	4. Additional Effects of Vasopressin
	4.1. Cardiovascular Effects
	4.2. Effects on the Pituitary
	4.3. CNS effects of Vasopressin
	5. Thirst
	6. The Integrated Physiology of Vasopressin and Thirst in Water Homeostasis
	7. The Physiology of Oxytocin
	7.1. Oxytocin and lactation
	7.2. Oxytocin and parturition
	7.3. Oxytocin and behavior
	7.4. Integrated physiology of Oxytocin
	PART 2. CLINICAL PROBLEMS SECONDARY TO DEFECTS IN THE HYPOTHALAMO-POSTERIOR PITUITARY AXIS
	1. Diabetes Insipidus
	1.1. Classification
	1.2. Hypothalamic Diabetes Insipidus (HDI)
	2. Nephrogenic Diabetes Insipidus (NDI)
	3. Dipsogenic Diabetes Insipidus (DDI)
	4. Syndrome of inappropriate antidiuresis
	4.1. Hyponatraemia
	4.2. Pathophysiology of SIAD
	4.3. Aetiology of SIAD
	4.4. Clinical features and diagnosis of SIAD
	4.5 Exercise associated hyponatraemia
	4.6 Nephrogenic syndrome of Inappropriate antidiuresis
	4.7 Central salt wasting
	4.8. Management of hyponatraemia secondary to SIAD
	5. Adipsic and hypodipsic syndromes
	5.1. Classification and etiology
	5.2. Management