1.         Morton H, Cavanagh AC, Athanasas-Platsis S, et al.: Early pregnancy factor has immunosuppressive and growth factor properties. Reprod Fertil Dev 4:411-22, 1992.

2.         Morton H, Rolfe BE, Cavanagh AC: Pregnancy proteins: basic concepts and clinical applications. Semin Reprod Endocrinol 10:72, 1992.

3.         Cavanagh AC, Morton H, Rolfe BE, et al.: Ovum factor: a first signal of pregnancy? Am J Reprod Immunol 2:97-101, 1982.

4.         Morton H, Rolfe BE, Cavanagh AC: Ovum factor and early pregnancy factor. Curr Top Dev Biol 23:73-92, 1987.

5.         Croxatto HB, Ortiz ME, Diaz S, et al.: Studies on the duration of egg transport by the human oviduct. II. Ovum location at various intervals following luteinizing hormone peak. Am J Obstet Gynecol 132:629-34, 1978.

6.         Buster JE, Bustillo M, Rodi IA, et al.: Biologic and morphologic development of donated human ova recovered by nonsurgical uterine lavage. Am J Obstet Gynecol 153:211-7, 1985.

7.         The morphological and functional development of the fetus. In Cunningham F, MacDonald P, Gant N [eds.] Williams Obstetrics. Eighteenth edition, 1989. Appleton & Lange, East Norwalk.

8.         Shutt DA, Lopata A: The secretion of hormones during the culture of human preimplantation embryos with corona cells. Fertil Steril 35:413-6, 1981.

9.         Laufer N, DeCherney AH, Haseltine FP, et al.: Steroid secretion by the human egg-corona-cumulus complex in culture. J Clin Endocrinol Metab 58:1153-7, 1984.

10.        Punnonen R, Lukola A: Binding of estrogen and progestin in the human fallopian tube. Fertil Steril 36:610-4, 1981.

11.        Hsueh AJ, Peck EJ, Jr., clark JH: Progesterone antagonism of the oestrogen receptor and oestrogen-induced uterine growth. Nature 254:337-9, 1975.

12.        Bonduelle ML, Dodd R, Liebaers I, et al.: Chorionic gonadotrophin-beta mRNA, a trophoblast marker, is expressed in human 8-cell embryos derived from tripronucleate zygotes. Hum Reprod 3:909-14, 1988.

13.        Lopata A, Hay DL: The surplus human embryo: its potential for growth, blastulation, hatching, and human chorionic gonadotropin production in culture. Fertil Steril 51:984-91, 1989.

14.        Hay DL, Lopata A: Chorionic gonadotropin secretion by human embryos in vitro. J Clin Endocrinol Metab 67:1322-4, 1988.

15.        Enders AC: Embryo implantation, with emphasis on the rhesus monkey and the human. Reproduccion 5:163-7, 1981.

16.        Tulchinsky D, Hobel CJ: Plasma human chorionic gonadotropin, estrone, estradiol, estriol, progesterone, and 17 alpha-hydroxyprogesterone in human pregnancy. 3. Early normal pregnancy. Am J Obstet Gynecol 117:884-93, 1973.

17.        Chard T: Proteins of the human placenta: some general concepts. p. In Grudzinskas J, Teisner B, Sepala M [eds.] Pregnancy Proteins: Biology, Chemistry and Clinical Application. Academic Press, San Diego, 1982.

18.        Saijonmaa O, Laatikainen T, Wahlstrom T: Corticotrophin-releasing factor in human placenta: localization, concentration and release in vitro. Placenta 9:373-85, 1988.

19.        Khodr GS, Siler-Khodr TM: Placental luteinizing hormone-releasing factor and its synthesis. Science 207:315-7, 1980.

20.        Shambaugh G, 3rd, Kubek M, Wilber JF: Thyrotropin-releasing hormone activity in the human placenta. J Clin Endocrinol Metab 48:483-6, 1979.

21.        Al-Timimi A, Fox H: Immunohistochemical localization of follicle-stimulating hormone, luteinizing hormone, growth hormone, adrenocorticotrophic hormone and prolactin in the human placenta. Placenta 7:163-72, 1986.

22.        Hay DL: Placental histology and the production of human choriogonadotrophin and its subunits in pregnancy. Br J Obstet Gynaecol 95:1268-75, 1988.

23.        Harada A, Hershman JM: Extraction of human chorionic thyrotropin (hCT) from term placentas: failure to recover thyrotropic activity. J Clin Endocrinol Metab 47:681-5, 1978.

24.        Steiner D: Peptide hormone precursors: biosynthesis, processing, and significance. p. 49. In Parson J [eds.] Peptide Hormones. University Park Press, Baltimore, 1976.

25.        Hoshina M, Hussa R, Pattillo R, et al.: The role of trophoblast differentiation in the control of the hCG and hPL genes. Adv Exp Med Biol 176:299-312, 1984.

26.        Hoshina M, Boime I, Mochizuki M: [Cytological localization of hPL, hCG, and mRNA in chorionic tissue using in situ hybridization]. Nippon Sanka Fujinka Gakkai Zasshi 36:397-404, 1984.

27.        Kurman RJ, Young RH, Norris HJ, et al.: Immunocytochemical localization of placental lactogen and chorionic gonadotropin in the normal placenta and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tumor. Int J Gynecol Pathol 3:101-21, 1984.

28.        Kasai K, Aochi H, Shik SS, et al.: [Production and localization of human prolactin in the tissues associated with pregnancy (Report I) (author's transl)]. Nippon Naibunpi Gakkai Zasshi 56:1574-80, 1980.

29.        Watkins WB, Yen SS: Somatostatin in cytotrophoblast of the immature human placenta: localization by immunoperoxidase cytochemistry. J Clin Endocrinol Metab 50:969-71, 1980.

30.        Chard T, Grudzinskas JG: Pregnancy protein secretion. Semin Reprod Endocrinol 10:61, 1992.

31.        Jones EE: Abnormal ovulation and implantation. p. 187. In Reece EA, Hobbins JC [eds.] Medicine of the mother and fetus. JB Lippincott Company, Philadelphia, 1992.

32.        Murphy BEP: Cortisol economy in the human fetus. p. 509. In James VHT, Serio M, Gusti G [eds.] The Endocrine Function of the Human Adrenal Cortex. Academic Press, San Diego, 1978.

33.        Murphy BE: Cortisol and cortisone in human fetal development. J Steroid Biochem 11:509-13, 1979.

34.        Handwerger S, Brar A: Placental lactogen, placental growth hormone, and decidual prolactin. Semin Reprod Endocrinol 10:106, 1992.

35.        Maslar IA, Ansbacher R: Effects of progesterone on decidual prolactin production by organ cultures of human endometrium. Endocrinology 118:2102-8, 1986.

36.        Raabe MA, McCoshen JA: Epithelial regulation of prolactin effect on amnionic permeability. Am J Obstet Gynecol 154:130-4, 1986.

37.        Clements JA, Reyes FI, Winter JS, et al.: Studies on human sexual development. IV. Fetal pituitary and serum, and amniotic fluid concentrations of prolactin. J Clin Endocrinol Metab 44:408-13, 1977.

38.        Luciano AA, Varner MW: Decidual, amniotic fluid, maternal and fetal prolactin in normal and abnormal pregnancies. Obstet Gynecol 63:384-8, 1984.

39.        Pullano JG, Cohen-Addad N, Apuzzio JJ, et al.: Water and salt conservation in the human fetus and newborn. I. Evidence for a role of fetal prolactin. J Clin Endocrinol Metab 69:1180-6, 1989.

40.        Golander A, Kopel R, Lazebnik N, et al.: Decreased prolactin secretion by decidual tissue of pre-eclampsia in vitro. Acta Endocrinol (Copenh) 108:111-3, 1985.

41.        Healy DL, Herington AC, O'Herlihy C: Chronic polyhydramnios is a syndrome with a lactogen receptor defect in the chorion laeve. Br J Obstet Gynaecol 92:461-7, 1985.

42.        McCoshen JA, Barc J: Prolactin bioactivity following decidual synthesis and transport by amniochorion. Am J Obstet Gynecol 153:217-23, 1985.

43.        Rutanen E: Insulin-like growth factor binding protein-1. Semin Reprod Endocrinol 10:154, 1992.

44.        Seppala M, Riittinen L, Kamarainen M: Placental protein 14/progesterone-associated endoemtrial protein revisited. Semin Reprod Endocrinol 10:164, 1992.

45.        Julkunen M, Rutanen EM, Koskimies A, et al.: Distribution of placental protein 14 in tissues and body fluids during pregnancy. Br J Obstet Gynaecol 92:1145-51, 1985.

46.        Stabile I, Olajide F, Chard T, et al.: Circulating levels of placental protein 14 in ectopic pregnancy. Br J Obstet Gynaecol 101:762-4, 1994.

47.        Carr BR, MacDonald PC, Simpson ER: The role of lipoproteins in the regulation of progesterone secretion by the human corpus luteum. Fertil Steril 38:303-11, 1982.

48.        Csapo AI, Pulkkinen MO, Wiest WG: Effects of luteectomy and progesterone replacement therapy in early pregnant patients. Am J Obstet Gynecol 115:759-65, 1973.

49.        Sauer MV, Paulson RJ, Lobo RA: A preliminary report on oocyte donation extending reproductive potential to women over 40. N Engl J Med 323:1157-60, 1990.

50.        Yen SS: Endocrine-metabolic adaptations in pregnancy. p. 940. In Yen SSC, Jaffe RB, Barbieri RL [eds.] Reproductive endocrinology: physiology, pathophysiology and clinical management. WB Saunders Company, Philadelphia, 1991.

51.        Nygren KG, Johansson ED, Wide L: Evaluation of the prognosis of threatened abortion from the peripheral plasma levels of progesterone, estradiol, and human chorionic gonadotropin. Am J Obstet Gynecol 116:916-22, 1973.

52.        Stovall TG, Ling FW, Carson SA, et al.: Serum progesterone and uterine curettage in differential diagnosis of ectopic pregnancy. Fertil Steril 57:456-7, 1992.

53.        Tulchinsky D, Hobel CJ, Yeager E, et al.: Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy. Am J Obstet Gynecol 112:1095-100, 1972.

54.        Dicztalusy E: Steroid metabolism in the feto-placental unit. p. In Pecile A, Finzi C [eds.] The Feto-Placental Unit. Excerpta Medica, Amsterdam, 1969.

55.        Pepe GJ, Albrecht ED: Actions of placental and fetal adrenal steroid hormones in primate pregnancy. Endocr Rev 16:608-48, 1995.

56.        Abraham GE, Odell WD, Swerdloff RS, et al.: Simultaneous radioimmunoassay of plasma FSH, LH, progesterone, 17-hydroxyprogesterone, and estradiol-17 beta during the menstrual cycle. J Clin Endocrinol Metab 34:312-8, 1972.

57.        Lindberg BS, Johansson ED, Nilsson BA: Plasma levels of nonconjugated oestrone, oestradiol-17beta and oestriol during uncomplicated pregnancy. Acta Obstet Gynecol Scand Suppl 32:21-36, 1974.

58.        Yen SS: Endocrine-metabolic adaptations in pregnancy. p. 943. In Yen SSC, Jaffe RB, Barbieri RL [eds.] Reproductive endocrinology: physiology, pathophysiology and clinical management. WB Saunders Company, Philadelphia, 1991.

59.        Siiteri PK, Febres F, Clemens LE, et al.: Progesterone and maintenance of pregnancy: is progesterone nature's immunosuppressant? Ann N Y Acad Sci 286:384-97, 1977.

60.        Moriyama I, Sugawa T: Progesterone facilitates implantation of xenogenic cultured cells in hamster uterus. Nat New Biol 236:150-2, 1972.

61.        Partsch CJ, Sippell WG, MacKenzie IZ, et al.: The steroid hormonal milieu of the undisturbed human fetus and mother at 16-20 weeks gestation. J Clin Endocrinol Metab 73:969-74, 1991.

62.        Tulchinsky D, Simmer HH: Sources of plasma 17alpha-hydroxyprogesterone in human pregnancy. J Clin Endocrinol Metab 35:799-808, 1972.

63.        Siiteri PK, MacDonald PC: Placental estrogen biosynthesis during human pregnancy. J Clin Endocrinol Metab 26:751-61, 1966.

64.        Bradshaw KD, Carr BR: Placental sulfatase deficiency: maternal and fetal expression of steroid sulfatase deficiency and X-linked ichthyosis. Obstet Gynecol Surv 41:401-13, 1986.

65.        Simpson ER, Mahendroo MS, Means GD, et al.: Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr Rev 15:342-55, 1994.

66.        Yen SS: Endocrine-metabolic adaptations in pregnancy. p. 947. In Yen SSC, Jaffe RB, Barbieri RL [eds.] Reproductive endocrinology: physiology, pathophysiology and clinical management. WB Saunders Company, Philadelphia, 1991.

67.        Resnik R, Killam AP, Battaglia FC, et al.: The stimulation of uterine blood flow by various estrogens. Endocrinology 94:1192-6, 1974.

68.        Henson MC, Pepe GJ, Albrecht ED: Regulation of placental low-density lipoprotein uptake in baboons by estrogen: dose-dependent effects of the anti-estrogen ethamoxytriphetol (MER-25). Biol Reprod 45:43-8, 1991.

69.        Tulchinsky D, Hobel CJ, Korenman SG: A radioligand assay for plasma unconjugated estriol in normal and abnormal pregnancies. Am J Obstet Gynecol 111:311-8, 1971.

70.        Landon MB, Gabbe SG: Fetal surveillance in the pregnancy complicated by diabetes mellitus. Clin Obstet Gynecol 34:535-43, 1991.

71.        Klopper A, Masson G, Campbell D, et al.: Estriol in plasma. A compartmental study. Am J Obstet Gynecol 117:21-6, 1973.

72.        Solomon S: The placenta as an endocrine organ: steroids. p. 2086. In Knobil E, Neill JD [eds.] The physiology of reproduction. Raven Press Ltd., New York, 1988.

73.        Barnea ER, Kaplan M: Spontaneous, gonadotropin-releasing hormone-induced, and progesterone-inhibited pulsatile secretion of human chorionic gonadotropin in the first trimester placenta in vitro. J Clin Endocrinol Metab 69:215-7, 1989.

74.        Chrousos GP, Calabrese JR, Avgerinos P, et al.: Corticotropin releasing factor: basic studies and clinical applications. Prog Neuropsychopharmacol Biol Psychiatry 9:349-59, 1985.

75.        Stalla GK, Hartwimmer J, von Werder K, et al.: Ovine (o) and human (h) corticotrophin releasing factor (CRF) in man: CRF-stimulation and CRF-immunoreactivity. Acta Endocrinol (Copenh) 106:289-97, 1984.

76.        Shibahara S, Morimoto Y, Furutani Y, et al.: Isolation and sequence analysis of the human corticotropin-releasing factor precursor gene. Embo J 2:775-9, 1983.

77.        Stalla GK, Bost H, Stalla J, et al.: Human corticotropin-releasing hormone during pregnancy. Gynecol Endocrinol 3:1-10, 1989.

78.        Laatikainen TJ, Raisanen IJ, Salminen KR: Corticotropin-releasing hormone in amniotic fluid during gestation and labor and in relation to fetal lung maturation. Am J Obstet Gynecol 159:891-5, 1988.

79.        Jones SA, Brooks AN, Challis JR: Steroids modulate corticotropin-releasing hormone production in human fetal membranes and placenta. J Clin Endocrinol Metab 68:825-30, 1989.

80.        Robinson BG, Emanuel RL, Frim DM, et al.: Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta. Proc Natl Acad Sci U S A 85:5244-8, 1988.

81.        Linton EA, Perkins AV, Woods RJ, et al.: Corticotropin releasing hormone-binding protein (CRH-BP): plasma levels decrease during the third trimester of normal human pregnancy. J Clin Endocrinol Metab 76:260-2, 1993.

82.        Sug-Tang A, Bocking AD, Brooks AN, et al.: Effects of restricting uteroplacental blood flow on concentrations of corticotrophin-releasing hormone, adrenocorticotrophin, cortisol, and prostaglandin E2 in the sheep fetus during late pregnancy. Can J Physiol Pharmacol 70:1396-402, 1992.

83.        Clifton VL, Read MA, Leitch IM, et al.: Corticotropin-releasing hormone-induced vasodilatation in the human fetal placental circulation. J Clin Endocrinol Metab 79:666-9, 1994.

84.        Perkins AV, Linton EA, Eben F, et al.: Corticotrophin-releasing hormone and corticotrophin-releasing hormone binding protein in normal and pre-eclamptic human pregnancies. Br J Obstet Gynaecol 102:118-22, 1995.

85.        Goland RS, Jozak S, Warren WB, et al.: Elevated levels of umbilical cord plasma corticotropin-releasing hormone in growth-retarded fetuses. J Clin Endocrinol Metab 77:1174-9, 1993.

86.        Ruth V, Hallman M, Laatikainen T: Corticotropin-releasing hormone and cortisol in cord plasma in relation to gestational age, labor, and fetal distress. Am J Perinatol 10:115-8, 1993.

87.        Goland RS, Conwell IM, Warren WB, et al.: Placental corticotropin-releasing hormone and pituitary-adrenal function during pregnancy. Neuroendocrinology 56:742-9, 1992.

88.        Youngblood WW, Humm J, Lipton MA, et al.: Thyrotropin-releasing hormone-like bioactivity in placenta: evidence for the existence of substances other than Pyroglu-His-Pro-NH2 (TRH) capable of stimulating pituitary thyrotropin release. Endocrinology 106:541-6, 1980.

89.        Taliadouros GS, Canfield RE, Nisula BC: Thyroid-stimulating activity of chorionic gonadotropin and luteinizing hormone. J Clin Endocrinol Metab 47:855-60, 1978.

90.        Ren SG, Braunstein GD: Human chorionic gonadotropin. Semin Reprod Endocrinol 10:95, 1992.

91.        Mersol-Barg MS, Miller KF, Choi CM, et al.: Inhibin suppresses human chorionic gonadotropin secretion in term, but not first trimester, placenta. J Clin Endocrinol Metab 71:1294-8, 1990.

92.        Hanson FW, Powell JE, Stevens VC: Effects of HCG and human pituitary LH on steroid secretion and functional life of the human corpus luteum. J Clin Endocrinol Metab 32:211-5, 1971.

93.        Nisula BC, Ketelslegers JM: Thyroid-stimulating activity and chorionic gonadotropin. J Clin Invest 54:494-9, 1974.

94.        Seron-Ferre M, Lawrence CC, Jaffee RB: Role of hCG in the regulation of the fetal adrenal gland. J Clin Endocrinol Metab 46:834, 1978.

95.        Huhtaniemi IT, Korenbrot CC, Jaffe RB: HCG binding and stimulation of testosterone biosynthesis in the human fetal testis. J Clin Endocrinol Metab 44:963-7, 1977.

96.        Hodgen GD, Itskovitz J: Recognition and maintenance of pregnancy. p. 2009. In Knobil E, Neill JD [eds.] The physiology of reproduction. Raven Press Ltd., New York, 1988.

97.        Frankenne F, Closset J, Gomez F, et al.: The physiology of growth hormones (GHs) in pregnant women and partial characterization of the placental GH variant. J Clin Endocrinol Metab 66:1171-80, 1988.

98.        Eriksson L, Frankenne F, Eden S, et al.: Growth hormone secretion during termination of pregnancy. Further evidence of a placental variant. Acta Obstet Gynecol Scand 67:549-52, 1988.

99.        Eriksson L: Growth hormone in human pregnancy. Maternal 24-hour serum profiles and experimental effects of continuous GH secretion. Acta Obstet Gynecol Scand Suppl 147:1-38, 1989.

100.      Eriksson L, Frankenne F, Eden S, et al.: Growth hormone 24-h serum profiles during pregnancy--lack of pulsatility for the secretion of the placental variant. Br J Obstet Gynaecol 96:949-53, 1989.

101.      Mirlesse V, Frankenne F, Alsat E, et al.: Placental growth hormone levels in normal pregnancy and in pregnancies with intrauterine growth retardation. Pediatr Res 34:439-42, 1993.

102.      Takata K, Kasahara T, Kasahara M, et al.: Localization of erythrocyte/HepG2-type glucose transporter (GLUT1) in human placental villi. Cell Tissue Res 267:407-12, 1992.

103.      Hauguel-de Mouzon S, Leturque A, Alsat E, et al.: Developmental expression of Glut1 glucose transporter and c-fos genes in human placental cells. Placenta 15:35-46, 1994.

104.      MacLeod JN, Lee AK, Liebhaber SA, et al.: Developmental control and alternative splicing of the placentally expressed transcripts from the human growth hormone gene cluster. J Biol Chem 267:14219-26, 1992.

105.      de Zegher F, Vanderschueren-Lodeweyckx M, Spitz B, et al.: Perinatal growth hormone (GH) physiology: effect of GH-releasing factor on maternal and fetal secretion of pituitary and placental GH. J Clin Endocrinol Metab 71:520-2, 1990.

106.      Evain-Brion D, Alsat E, Mirlesse V, et al.: Regulation of growth hormone secretion in human trophoblastic cells in culture. Horm Res 33:256-9, 1990.

107.      Han VK, Bassett N, Walton J, et al.: The expression of insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) genes in the human placenta and membranes: evidence for IGF-IGFBP interactions at the feto-maternal interface. J Clin Endocrinol Metab 81:2680-93, 1996.

108.      Raben MS, Matsuzaki F, Minton PR: Growth-Promoting and Metabolic Effects of Growth Hormone. Metabolism 13:SUPPL:1102-7, 1964.

109.      Salomon F, Cuneo RC, Hesp R, et al.: The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 321:1797-803, 1989.

110.      Yen SS: Endocrine-metabolic adaptations in pregnancy. p. 958. In Yen SSC, Jaffe RB, Barbieri RL [eds.] Reproductive endocrinology: physiology, pathophysiology and clinical management. WB Saunders Company, Philadelphia, 1991.

111.      Niall HD, Hogan ML, Sauer R, et al.: Sequences of pituitary and placental lactogenic and growth hormones: evolution from a primordial peptide by gene reduplication. Proc Natl Acad Sci U S A 68:866-70, 1971.

112.      Braunstein GD, Rasor JL, Engvall E, et al.: Interrelationships of human chorionic gonadotropin, human placental lactogen, and pregnancy-specific beta 1-glycoprotein throughout normal human gestation. Am J Obstet Gynecol 138:1205-13, 1980.

113.      Kim YJ, Felig P: Plasma chorionic somatomammotropin levels during starvation in midpregnancy. J Clin Endocrinol Metab 32:864-7, 1971.

114.      Furlanetto RW, Underwood LE, Van Wyk JJ, et al.: Serum immunoreactive somatomedin-C is elevated late in pregnancy. J Clin Endocrinol Metab 47:695-8, 1978.

115.      Kirwan JP, Hauguel-De Mouzon S, Lepercq J, et al.: TNF-alpha is a predictor of insulin resistance in human pregnancy. Diabetes 51:2207-13, 2002.

116.      Navot D, Scott RT, Droesch K, et al.: The window of embryo transfer and the efficiency of human conception in vitro. Fertil Steril 55:114-8, 1991.

117.      Lenton EA, Neal LM, Sulaiman R: Plasma concentrations of human chorionic gonadotropin from the time of implantation until the second week of pregnancy. Fertil Steril 37:773-8, 1982.

118.      Kosasa T, Levesque L, Goldstein DP, et al.: Early detection of implantation using a radioimmunoassay specific for human chorionic gonadotropin. J Clin Endocrinol Metab 36:622-4, 1973.

119.      Cavanagh AC, Morton H: The purification of early-pregnancy factor to homogeneity from human platelets and identification as chaperonin 10. Eur J Biochem 222:551-60, 1994.

120.      Di Trapani G, Orosco C, Perkins A, et al.: Isolation from human placental extracts of a preparation possessing 'early pregnancy factor' activity and identification of the polypeptide components. Hum Reprod 6:450-7, 1991.

121.      Zuo X, Su B, Wei D: Isolation and characterization of early pregnancy factor. Chin Med Sci J 9:34-7, 1994.

122.      Mehta AR, Eessalu TE, Aggarwal BB: Purification and characterization of early pregnancy factor from human pregnancy sera. J Biol Chem 264:2266-71, 1989.

123.      Clarke FM: Identification of molecules and mechanisms involved in the 'early pregnancy factor' system. Reprod Fertil Dev 4:423-33, 1992.

124.      Chard T, Grudzinskas JG: Early pregnancy factor. Biol Res Pregnancy Perinatol 8:53-6, 1987.

125.      Mesrogli M, Schneider J, Maas DH: Early pregnancy factor as a marker for the earliest stages of pregnancy in infertile women. Hum Reprod 3:113-5, 1988.

126.      Shahani SK, Moniz CL, Bordekar AD, et al.: Early pregnancy factor as a marker for assessing embryonic viability in threatened and missed abortions. Gynecol Obstet Invest 37:73-6, 1994.

127.      Straube W, Romer T, Zeenni L, et al.: [The early pregnancy factor (EPF) as an early marker of disorders in pregnancy]. Zentralbl Gynakol 117:32-4, 1995.

128.      Hubel V, Straube W, Loh M, et al.: Human early pregnancy factor and early pregnancy associated protein before and after therapeutic abortion in comparison with beta-hCG, estradiol, progesterone and 17-hydroxyprogesterone. Exp Clin Endocrinol 94:171-6, 1989.

129.      Rees LH, Burke CW, Chard T, et al.: Possible placental origin of ACTH in normal human pregnancy. Nature 254:620-2, 1975.

130.      Genazzani AR, Fraioli F, Hurlimann J, et al.: Immunoreactive ACTH and cortisol plasma levels during pregnancy. Detection and partial purification of corticotrophin-like placental hormone: the human chorionic corticotrophin (HCC). Clin Endocrinol (Oxf) 4:1-14, 1975.

131.      Petraglia F, Sawchenko PE, Rivier J, et al.: Evidence for local stimulation of ACTH secretion by corticotropin-releasing factor in human placenta. Nature 328:717-9, 1987.

132.      Nolten WE, Rueckert PA: Elevated free cortisol index in pregnancy: possible regulatory mechanisms. Am J Obstet Gynecol 139:492-8, 1981.

133.      Prager D, Weber MM, Herman-Bonert V: Placental growth factors and releasing/inhibiting peptides. Semin Reprod Endocrinol 10:83, 1992.

134.      Abe Y, Hasegawa Y, Miyamoto K, et al.: High concentrations of plasma immunoreactive inhibin during normal pregnancy in women. J Clin Endocrinol Metab 71:133-7, 1990.

135.      Tovanabutra S, Illingworth PJ, Ledger WL, et al.: The relationship between peripheral immunoactive inhibin, human chorionic gonadotrophin, oestradiol and progesterone during human pregnancy. Clin Endocrinol (Oxf) 38:101-7, 1993.

136.      Petraglia F, Sawchenko P, Lim AT, et al.: Localization, secretion, and action of inhibin in human placenta. Science 237:187-9, 1987.

137.      Muttukrishna S, George L, Fowler PA, et al.: Measurement of serum concentrations of inhibin-A (alpha-beta A dimer) during human pregnancy. Clin Endocrinol (Oxf) 42:391-7, 1995.

138.      Khong TY, Healy DL, Findlay JK, et al.: Inhibin and the human placenta: a critique. Reprod Fertil Dev 3:391-5, 1991.

139.      Petraglia F: Inhibin, activin and follistatin in the human placenta--a new family of regulatory proteins. Placenta 18:3-8, 1997.

140.      Mills NC, D'Ercole AJ, Underwood LE, et al.: Synthesis of somatomedin C/insulin-like growth factor I by human placenta. Mol Biol Rep 11:231-6, 1986.

141.      Jonas HA, Harrison LC: The human placenta contains two distinct binding and immunoreactive species of insulin-like growth factor-I receptors. J Biol Chem 260:2288-94, 1985.

142.      Grizzard JD, D'Ercole AJ, Wilkins JR, et al.: Affinity-labeled somatomedin-C receptors and binding proteins from the human fetus. J Clin Endocrinol Metab 58:535-43, 1984.

143.      Lenton EA, Grudzinskas JG, Gordon YB, et al.: Pregnancy specific beta 1 glycoprotein and chorionic gonadotrophin in early human pregnancy. Acta Obstet Gynecol Scand 60:489-92, 1981.

144.      Chou JY, Plouzek CA: Pregnancy-specific 3t-glycoprotein. Semin Reprod Endocrinol 10:116, 1992.

145.      Tatarinov YS: Trophoblast-specific beta1-glycoprotein as a marker for pregnancy and malignancies. Gynecol Obstet Invest 9:65-97, 1978.

146.      Sinosich MJ, Teisner B, Folkersen J, et al.: Radioimmunoassay for pregnancy-associated plasma protein A. Clin Chem 28:50-3, 1982.

147.      Bischof P: Pregnancy-associated plasma protein-A. Semin Reprod Endocrinol 10:127, 1992.

148.      Westergaard JG, Teisner B, Sinosich MJ, et al.: Does ultrasound examination render biochemical tests obsolete in the prediction of early pregnancy failure? Br J Obstet Gynaecol 92:77-83, 1985.

149.      Dumps P, Meisser A, Pons D, et al.: Accuracy of single measurements of pregnancy-associated plasma protein-A, human chorionic gonadotropin and progesterone in the diagnosis of early pregnancy failure. Eur J Obstet Gynecol Reprod Biol 100:174-80, 2002.

150.      Obiekwe B, Pendlebury DJ, Gordeon YB, et al.: The radioimmunoassay of placental protein 5 and circulating levels in maternal blood in the third trimester of normal pregnancy. Clin Chim Acta 95:509-16, 1979.

151.      Salem HT, Seppala M, Chard T: The effect of thrombin on serum placental protein 5 (PP5): is PP5 the naturally occurring antithrombin III of the human placenta? Placenta 2:205-9, 1981.

152.      Flood JT, Hodgen GD: The physiology of fertilization, implantation and early human development. p. 88. In Scott JR, Desaia PJ [eds.] Danforth's Obstetrics and Gynecology. JB Lippincott Company, Philadelphia, 1990.

153.      Winn VD, Haimov-Kochman R, Paquet AC, et al.: Gene expression profiling of the human maternal-fetal interface reveals dramatic changes between midgestation and term. Endocrinology 148:1059-79, 2007.

154.      Parker CR: The endocrinology of pregnancy. p. 28. In Carr BR, Blackwell RE [eds.] Textbook of Reproductive Medicine. Appleton & Lange, Norwalk, 1993.

155.      Johannison E: The foetal adrenal cortex in the human. Acta Endocrinol 58(Suppl. 130):7, 1968.

156.      Honour JH, Wickramaratne K, Valman HB: Adrenal function in preterm infants. Biol Neonate 61:214-21, 1992.

157.      Hutchinson KA, DeCherney AH: The endocrinology of pregnancy. p. 105. In Reece EA, Hobbins JC [eds.] Medicine of the mother and fetus. JB Lippincott Company, Philadelphia, 1999.

158.      The morphological and functional development of the fetus. In Cunningham FG, MacDonald PC, Gant NF [eds.] Williams Obstetrics. Eighteenth edition, 1989. Appleton & Lange, East Norwalk.

159.      Alpert E, Drysdale JW, Isselbacher KJ, et al.: Human -fetoprotein. Isolation, characterization, and demonstration of microheterogeneity. J Biol Chem 247:3792-8, 1972.

160.      Gitlin D, Perricelli A, Gitlin GM: Synthesis of -fetoprotein by liver, yolk sac, and gastrointestinal tract of the human conceptus. Cancer Res 32:979-82, 1972.

161.      Habib ZA: Maternal serum alpha-feto-protein: its value in antenatal diagnosis of genetic disease and in obstetrical-gynaecological care. Acta Obstet Gynecol Scand Suppl 61:1-92, 1977.

162.      Murgita RA, Tomasi TB, Jr.: Suppression of the immune response by alpha-fetoprotein on the primary and secondary antibody response. J Exp Med 141:269-86, 1975.

163.      Ferguson-Smith MA, Rawlinson HA, May HM, et al.: Avoidance of anencephalic and spina bifida births by maternal serum-alphafetoprotein screening. Lancet 1:1330-3, 1978.

164.      Wald N, Cuckle H: AFP and age screening for Down syndrome. Am J Med Genet 31:197-209, 1988.

165.      Burrow GN, Fisher DA, Larsen PR: Maternal and fetal thyroid function. N Engl J Med 331:1072-8, 1994.

166.      Pepe GJ, Waddell BJ, Albrecht ED: The effects of adrenocorticotropin and prolactin on adrenal dehydroepiandrosterone secretion in the baboon fetus. Endocrinology 122:646-50, 1988.

167.      Pepe GJ, Albrecht ED: Regulation of the primate fetal adrenal cortex. Endocr Rev 11:151-76, 1990.

168.      Albrecht ED, Pepe GJ: Placental steroid hormone biosynthesis in primate pregnancy. Endocr Rev 11:124-50, 1990.

169.      Carr BR, MacDonald PC, Simpson ER: The regulation of de novo synthesis of cholesterol in the human fetal adrenal gland by low density lipoprotein and adrenocorticotropin. Endocrinology 107:1000-6, 1980.

170.      Carr BR, Porter JC, MacDonald PC, et al.: Metabolism of low density lipoprotein by human fetal adrenal tissue. Endocrinology 107:1034-40, 1980.

171.      Parker CR, Jr., Carr BR, Winkel CA, et al.: Hypercholesterolemia due to elevated low density lipoprotein-cholesterol in newborns with anencephaly and adrenal atrophy. J Clin Endocrinol Metab 57:37-43, 1983.

172.      Simpson ER, Carr BR, Parker CR, Jr., et al.: The role of serum lipoproteins in steroidogenesis by the human fetal adrenal cortex. J Clin Endocrinol Metab 49:146-8, 1979.

173.      Winters AJ, Oliver C, Colston C, et al.: Plasma ACTH levels in the human fetus and neonate as related to age and parturition. J Clin Endocrinol Metab 39:269-73, 1974.

174.      Simpson ER, Parker CR, Jr., Carr BR: Role of lipoproteins in the regulation of steroidogenesis by the human fetal adrenal. p. In Jaffe RB, Dell Acqua S [eds.] The Endocrine Physiology of Pregnancy and the Peripartal Period Vol. 21. Serono Symposia Publications. Raven Press, New York, 1985.

175.      Nieman LK: The endocrinology of pregnancy. p. 250. [eds.] Serono symposia in Reproductive Endocrinology.

176.      Seron-Ferre M, Lawrence CC, Siiteri PK, et al.: Steroid production by definitive and fetal zones of the human fetal adrenal gland. J Clin Endocrinol Metab 47:603-9, 1978.

177.      Baird A, Kan KW, Solomon S: Role of pro-opiomelanocortin-derived peptides in the regulation of steroid production by human fetal adrenal cells in culture. J Endocrinol 97:357-67, 1983.

178.      Bugnon C, Lenys D, Bloch B, et al.: [Cyto-immunologic study of early cell differentiation phenomena in the human fetal anterior pituitary gland]. C R Seances Soc Biol Fil 168:460-5, 1974.

179.      Katikineni M, Davies TF, Catt KJ: Regulation of adrenal and testicular prolactin receptors by adrenocorticotropin and luteinizing hormone. Endocrinology 108:2367-74, 1981.

180.      Voutilainen R, Miller WL: Coordinate tropic hormone regulation of mRNAs for insulin-like growth factor II and the cholesterol side-chain-cleavage enzyme, P450scc [corrected], in human steroidogenic tissues. Proc Natl Acad Sci U S A 84:1590-4, 1987.

181.      Winters AJ, Colston C, MacDonald PC, et al.: Fetal plasma prolactin levels. J Clin Endocrinol Metab 41:626-9, 1975.

182.      Walsh SW, Norman RL, Novy MJ: In utero regulation of rhesus monkey fetal adrenals: effects of dexamethasone, adrenocorticotropin, thyrotropin-releasing hormone, prolactin, human chorionic gonadotropin, and alpha-melanocyte-stimulating hormone on fetal and maternal plasma steroids. Endocrinology 104:1805-13, 1979.

183.      Liggins GC: Endocrinology of the foeto-maternal unit. p. In Sherman RP [eds.] Human Reproductive Physiology. Blackwell Scientific Publications, Oxford, 1972.

184.      Baggia S, Albrecht ED, Pepe GJ: Regulation of 11 beta-hydroxysteroid dehydrogenase activity in the baboon placenta by estrogen. Endocrinology 126:2742-8, 1990.

185.      Jost A: The fetal adrenal cortex. p. 426. In Creep RO, Astwood WB [eds.] Handbook of Physiology. Endocrinology Amer Physiol Soc, Washington, DC, 1975.

186.      Kondo S: Developmental studies on the Japanese human adrenals, I: ponderal growth. Bull Exp Biol 9:51, 1959.

187.      Spector DVS: Handbook of Biological Data. WB Saunders, Philadelphia. 1956.

188.      Fant M, Munro H, Moses AC: An autocrine/paracrine role for insulin-like growth factors in the regulation of human placental growth. J Clin Endocrinol Metab 63:499-505, 1986.

189.      Han VK, Lund PK, Lee DC, et al.: Expression of somatomedin/insulin-like growth factor messenger ribonucleic acids in the human fetus: identification, characterization, and tissue distribution. J Clin Endocrinol Metab 66:422-9, 1988.

190.      Berkowitz GS, Lapinski RH, Lockwood CJ, et al.: Corticotropin-releasing factor and its binding protein: maternal serum levels in term and preterm deliveries. Am J Obstet Gynecol 174:1477-83, 1996.

191.      McGrath S, McLean M, Smith D, et al.: Maternal plasma corticotropin-releasing hormone trajectories vary depending on the cause of preterm delivery. Am J Obstet Gynecol 186:257-60, 2002.

192.      Benedetto C, Petraglia F, Marozio L, et al.: Corticotropin-releasing hormone increases prostaglandin F2 alpha activity on human myometrium in vitro. Am J Obstet Gynecol 171:126-31, 1994.

193.      Karalis K, Goodwin G, Majzoub JA: Cortisol blockade of progesterone: a possible molecular mechanism involved in the initiation of human labor. Nat Med 2:556-60, 1996.

194.      Case ML, MacDonald PC: Human parturition: distinction between the initiation of parturition and the onset of labor. Semin Reprod Endocrinol 11:272, 1993.

195.      Olson DM, Zakar T: Intrauterine tissue prostaglandin synthesis: regulatory mechanisms. Semin Reprod Endocrinol 11:234, 1993.

196.      Parker CR, Jr., Leveno K, Carr BR, et al.: Umbilical cord plasma levels of dehydroepiandrosterone sulfate during human gestation. J Clin Endocrinol Metab 54:1216-20, 1982.

197.      Mesiano S, Chan EC, Fitter JT, et al.: Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium. J Clin Endocrinol Metab 87:2924-30, 2002.

198.      Csapo AI: Anti-progesterones in fertility control. p. 16. In Zatuchn'i GI, Sciarra JJ, Speidel JJ [eds.] Pregnancy Termination: Procedures, Safety and New Developments. Harper & Row, Hagerstown, 1979.

199.      Johnson JW, Austin KL, Jones GS, et al.: Efficacy of 17alpha-hydroxyprogesterone caproate in the prevention of premature labor. N Engl J Med 293:675-80, 1975.

200.      Yemini M, Borenstein R, Dreazen E, et al.: Prevention of premature labor by 17 alpha-hydroxyprogesterone caproate. Am J Obstet Gynecol 151:574-7, 1985.

201.      Meis PJ, Klebanoff M, Thom E, et al.: Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med 348:2379-85, 2003.

202.      Honnebier WJ, Swaab DF: The influence of anencephaly upon intrauterine growth of fetus and placenta and upon gestation length. J Obstet Gynaecol Br Commonw 80:577-88, 1973.

203.      Novy MJ: Hormonal regulation of parturition in primates. p. In Sciara J [eds.] Hormone Cell Interactions in Reproductive Tissues. Masson Publishing, New York, 1983.

204.      Hirst JJ, Chibbar R, Mitchell BF: Role of oxytocin in the regulation of uterine activity during pregnancy and in the initiation of labor. Semin Reprod Endocrinol 11:219, 1993.

205.      Ducsay CA, Seron-Ferre M, Germain AM, et al.: Endocrine and uterine activity rhythms in the perinatal period. Semin Reprod Endocrinol 11:285, 1993.

206.      Honnebier MB, Nathanielsz PW: Primate parturition and the role of the maternal circadian system. Eur J Obstet Gynecol Reprod Biol 55:193-203, 1994.

207.      Patrick J, Challis J, Campbell K, et al.: Circadian rhythms in maternal plasma cortisol and estriol concentrations at 30 to 31, 34 to 35, and 38 to 39 weeks' gestational age. Am J Obstet Gynecol 136:325-34, 1980.

208.      Haluska GJ, Novy MJ: Hormonal modulation of uterine activity during primate parturition. Semin Reprod Endocrinol 11:272, 1993.

 

 

In addition to the journal and text references listed above, the following sources were used in the preparation of this chapter:

 

Gabbe SG, Niebyl JR, Simpson JL [eds.]. Obstetrics: normal and problems pregnancies. Fifth edition, 2007. Churchill-Livingstone, New York.

 

Benirschke K, Kaufmann P, Baergen RN [eds.]. Pathology of the human placenta. Fifth edition, 2006. Springer, New York.

 

Strauss JF, Barbieri RL [eds.]. Yen and Jaffe’s Reproductive endocrinology: physiology, pathophysiology and clinical management. Fifth edition, 2004. Elsevier Saunders, Philadelphia.

 

Reece EA, Hobbins JC [eds.]. Clinical obstetrics: the fetus and mother. Third edition, 2007. Wiley-Blackwell, Malden, MA.